Cross-Sectional Gastric Cancer Tumor Location Prognostic for Long-Term Survival

Submitted by admin5 on Sat, 10/07/2017 - 13:17

A recent study reports that the cross-sectional location of gastric cancer is associated with long-term survival outcomes of patients as tumor invasion deepens, published in Annals of Surgical Oncology (online October 4, 2017; doi:10.1245/s10434-017-6101-2).

The prognosis of gastric cancer is often times determined by tumor depth and lymph node metastasis. However, the effect of cross-sectional tumor location on prognosis remains to be fully understood.

A group of Korean researchers led by Yoon Ju Jung, department of surgery, College of Medicine, Seoul St Mary’s Hospital, The Catholic University of Korea, conducted a study to determine the prognostic implications of cross-sectional gastric cancer tumor location in patients. Researchers recruited 4820 patients who had been diagnosed with gastric cancer and underwent gastrectomy from 1989 to 2012. Cross-sectional location of the tumors was categorized into four regions: lesser curvatures (LC), greater curvatures (GC), anterior walls (AW) and posterior walls (PW).

Researchers noted that the most common tumor site among the four cross-sectional locations in the patient population was the LC (46.4%). Proportions of the other three cross-sectional locations were similar (PW, 19.9%; AW, 18.4%, GC, 15.4%).

Results of the analysis showed that overall survival was significantly different  (P = .013) for patients depending on the cross-sectional location of their tumors. The categorization most associated with survival outcome was GC; five-year overall survival of those with tumors with a GC categorization was significantly worse (P = .003) than for those with any of the other three categorizations.


Related Content

Novel Prognostic Indicator Found in Gastric Cancer

Gastric Cancer Prediction Model Could Help Guide Therapy


Subgroup multivariate analysis further revealed that GC location was an independent prognostic indicator for worse clinical outcome at T stage 3-4b (HR, 1.37; 95% CI, 1.15-1.62; P < .001). Additionally, researchers noted that a GC tumor had a higher recurrence rate in terms of peritoneal seeding compared with other tumor locations.

Authors of the study concluded that cross-sectional location of gastric cancer tumors is significantly associated with long-term survival. A poor prognosis is given for patients with a GC location and deeper T stages.—Zachary Bessette