A large genomic characterization study found specific somatic copy number alterations to have prognostic implications for metastasis, resistance, and novel therapeutic approaches in metastatic triple-negative breast cancer.

Conferences

Genomic analysis revealed differences in the landscape of estrogen receptor-positive cancers when compared with ER+ primary tumors.

Extended observation for adverse reactions following subcutaneously administered trastuzumab (Herceptin, Genentech/Roche) serves as an unnecessary use of health care resources, according to the results of a single-institution study.

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Common menopausal symptoms such as nausea and headaches can be used as predictive tools for adherence to the aromatase inhibitor tamoxifen, according to an analysis of data from the International Breast Cancer Intervention Study (IBIS-1).

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A study presented at the 2016 American Society of Clinical Oncology Annual Meeting (June 3-7; Chicago, IL) has found that the costs associated with different breast cancer chemotherapy regimens can vary significantly, regardless of effectiveness.

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News

A large genomic characterization study found specific somatic copy number alterations to have prognostic implications for metastasis, resistance, and novel therapeutic approaches in metastatic triple-negative breast cancer.
A newly introduced breast cancer prognostic stage from the American Joint Committee on Cancer is more accurate than the anatomic stage and should be implemented in clinical practice, researchers say.
The majority of women who had surgery for breast cancer said they did not feel fully informed about their treatment options, but a web-based decision aid tool may better help their understanding.
Breast cancer tumors treated with neoadjuvant chemotherapy may have higher risk of local recurrence after breast-conserving therapy than tumors treated with adjuvant chemotherapy.

Quiz

A recent study suggests that which treatment option(s) plus pertuzumab results in improved pathological complete responses in patients with HER2-Positive Breast Cancer?
According to recent research, which therapy reduces the risk of relapse in HER2-positive breast cancer?
According to a recent study, which therapy is most cost-effective for reducing the risk of skeletal events in breast cancer?

Research in Review

Patients with human epidermal growth factor 2 (HER2)-positive breast cancer who undergo induction chemotherapy are likely to convert to HER2-negative disease if residual disease occurs, prompting further systemic therapy, according to research presented at the 2017 ASCO Annual Meeting (June 2-6, 2017; Chicago, IL).

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Patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer benefit from an estimated 7 additional months of survival if treated with trastuzumab emtansine rather than the physician’s choice of therapy, according to research published in The Lancet Oncology [published online May 16, 2017; doi:10.1016/S1470-2045(17)30313-3].

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A radiation schedule half the standard course is as safe and effective for patients with breast cancer following a mastectomy, according to a study published in the Journal of Clinical Oncology (published online May 1, 2017; doi:10.1200/JCO.2016.70.7158).

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MRI results after percutaneous biopsy for ductal carcinoma in situ (DCIS) often overestimate the extent of breast cancer, resulting in unnecessary mastectomies, according to a presentation at the American Society of Breast Surgeons annual meeting (April 26-30, 2017; abstract 257324).

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