A large genomic characterization study found specific somatic copy number alterations to have prognostic implications for metastasis, resistance, and novel therapeutic approaches in metastatic triple-negative breast cancer.

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By Megan Brooks

NEW YORK (Reuters Health) - Omitting radiation after lumpectomy for pure ductal carcinoma in situ (DCIS) does not improve the chance of breast preservation in case of local recurrence, researchers from Canada have observed.

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A recent comparative effectiveness study examined long-term survival outcomes for patients with multiple stages of breast cancer after undergoing either mastectomy or breast-conserving surgery, published in the Journal of Global Oncology (August 2017;3[4]:304-313).

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Researchers examined the decision-making processes of patients with breast cancer to understand why a procedure that does not improve survival is increasingly being considered.

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IBM’s Watson for Oncology, a computer that helps oncologists make treatment decisions for individual patients, made the same recommendations 90% of the time as a team of specialist oncologists, according to a new study presented on Friday, December 9, at the San Antonio Breast Cancer Symposium.

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Research in Review

Use of the 21-gene recurrence score (RS) assay is helping clinicians and patients decide which treatments are best for them, according to a large-scale survey of more than 3000 women treated for breast cancer.

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Adjuvant endocrine therapy with tamoxifen or aromatase inhibitors may reduce the risk for contralateral breast cancer (CBC) in women with invasive breast cancer according to results from a study published in JAMA Oncology.

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Response-guided neoadjuvant chemotherapy (RG-NACT) is more cost effective than conventional NACT for estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer, according to a study published in BMC Cancer.

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Perceived barriers to treatment may predict patient nonadherence to aromatase inhibitors for women with early-stage, estrogen receptor-positive breast cancer, claims a study published in Cancer.

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