A recent study examined the association between colorectal cancer messenger RNA (mRNA) expression of HER3 with response to anti-EGFR agents, published in JAMA Oncology (online October 26, 2017; doi:10.1001/jamaoncol.2017.3168).

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Conferences

A novel scoring system may identify elderly patients with advanced gastric cancer who may not benefit from chemotherapy.

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Modified chemotherapy advised for gastric cancer

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A pilot program for Direct Access Colonoscopy Screening (DACS) increased overall screening rates for colorectal cancer by nearly 100% in a selected cohort, according to study results.
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Costs associated with maintenance bevacizumab (Avastin, Genentech/Roche) and capecitabine for patients with metastatic colorectal cancer exceeded willingness-to-pay thresholds and were not deemed cost-effective, according to an analysis of randomized trial data.

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The cost of colon cancer care rose significantly during the period from 2003 to 2013, despite decreases in overall hospitalizations and lengths of stay.

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News

A recent study examined the association between colorectal cancer messenger RNA (mRNA) expression of HER3 with response to anti-EGFR agents, published in JAMA Oncology (online October 26, 2017; doi:10.1001/jamaoncol.2017.3168).

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A pooled analysis investigated the prognostic role of DNA mismatch repair (MMR) status in patients with stage III colon cancer treated with a standard adjuvant chemotherapy regimen, published in JAMA Oncology (online October 5, 2017; doi:10.1001/jamaoncol.2017.2899).

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Recent research has uncovered an association between tumor origin and mortality among patients receiving systemic chemotherapy plus biologic therapy for metastatic colorectal cancer, published in JAMA Surgery (online September 20, 2017; doi:10.1001/jamasurg.2017.3466).

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Sequencing cell-free DNA may be able to provide baseline information on actionable mutations and improve the quality of care in colorectal cancer, according to recent research published in PLOS One (online August 29, 2017; doi:10.1371/journal.pone.0183949).

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Research in Review

Patients aged 45 years or younger with colorectal cancer may have better treatment options available to them because of more mutations in their tumors than older patients, according to research that will be presented at the 2017 ASCO Annual Meeting (June 2-6, 2017; Chicago, IL).

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Patients with rectal cancer who undergo first-line chemotherapy and radiation have lower risk of recurrence and higher rates of survival regardless of whether they choose to have surgery, according to a study published in The Lancet Gastroenterology & Hepatology (published online May 4, 2017: doi:10.1016/S2468-1253(17)30074-2).

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Patients with colorectal cancer can decrease their risk of disease-related mortality by 54% if they consume certain types of food, according to a study presented at Digestive Disease Week (May 6-9, 2017; Chicago, IL; abstract 82).

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Patients with a specific type of metastatic colorectal cancer who are chemotherapy-resistant benefit from treatment with a gene-targeting regimen.

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