Patients with colon cancer who followed the American Cancer Society’s Nutrition and Physical Activity Guidelines for Cancer Survivors have improved 5-year survival rates.

Conferences

The cost of colon cancer care rose significantly during the period from 2003 to 2013, despite decreases in overall hospitalizations and lengths of stay.

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In an early session at the Clinical Pathways Congress, Bert H O’Neil, MD, Indian University Simon Cancer Center (Indianapolis, IN) discussed some of the important factors to consider when developing a clinical pathway for colorectal cancer.

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Post-operative chemotherapy may be just as effective as chemoradiotherapy in patients with gastric cancer who have already undergone pre-operative chemotherapy, according to phase III data presented at the European Society for Medical Oncology (ESMO) 18th World Congress of Gastrointestinal Cancer (June 29 – July 2, 2016; Barcelona, Spain).

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Lymph node ratio (LNR) may be a significant indicator of prognosis in patients with rectal cancer and could be used to better stratify patients in clinical trials, claims a recently published study. 

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News

Patients receiving total neoadjuvant therapy may benefit in the short-term compared with those receiving traditional chemoradiation and adjuvant chemotherapy for locally advanced rectal cancer.
A recent study presented at the 2018 Gastrointestinal Cancers Symposium identified the difference between right-sided and left-sided tumors in regard to disease-free survival outcomes in patients with late stage, high-risk colorectal cancer.
A liquid biopsy can detect colorectal cancer at an early stage and with accuracy near 90%, according to research scheduled to be presented at the 2018 Gastrointestinal Cancers Symposium (January 18-20, 2018; San Francisco, CA).
Approximately 20% of individuals younger than age 50 who are diagnosed with colorectal cancer carry a germline mutation associated with cancer, despite having no clinical or family history of the disease.

Research in Review

Short-course preoperative radiotherapy combined with delayed surgery reduces the adverse effects of rectal cancer surgery while maintaining its efficiency, according to a study published in The Lancet (published online February 9, 2017; doi: 10.1016/S1470-2045(17)30086-4).

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Chemotherapy may be overused among young and middle-aged patients with colon cancer, according to a study published in JAMA Surgery (published online January 25, 2017; doi: 10.1001/jamasurg.2016.5050).
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The addition of BRAF-inhibitor vemurafenib to irinotecan and cetuximab chemotherapy treatment improves progression-free survival (PFS) for patients with BRAF-mutant metastatic colorectal cancer, according to a presentation at the Gastrointestinal Cancers Symposium.
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The immune checkpoint inhibitor nivolumab has shown durable responses and disease control in pretreated patients with DNA mismatch repair deficient/microsatellite instability high (MSI-H) metastatic colorectal cancer, according to a presentation at the Gastrointestinal Cancers Symposium.

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