In patients with hypopharyngeal and laryngeal cancers, the number of metastatic lymph nodes is independently associated with mortality, according to a recent study.

Conferences

Treatment with nivolumab reduced the risk of death and improved one-year overall survival (OS) compared with investigator’s choice of therapy for patients with recurrent or metastatic head and neck squamous cell carcinoma, according to clinical trial findings presented at the 2016 American Association for Cancer Research Annual Meeting (April 16-20; New Orleans, LA).

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News

In patients with hypopharyngeal and laryngeal cancers, the number of metastatic lymph nodes is independently associated with mortality, according to a recent study.
A recent comparative study examined whether chemotherapy alone is as effective as adjuvant radiotherapy plus chemotherapy in patients with high-risk grade 2 glioma.
Survivors of thyroid cancer who were younger than 40 years at diagnosis have a higher risk of developing age-related diseases compared with older patients or those who never had cancer.
For patients with oropharyngeal squamous cell carcinoma receiving transoral robotic surgery, adjuvant radiotherapy or chemoradiotherapy should be avoided if possible, according to a long-term functional and quality-of-life outcomes study.

Research in Review

A recent study suggests that immunotherapies targeting both PD-L1 and PD-L2 may enhance response rates for patients with head and neck squamous cell carcinoma (HNSCC), published in Clinical Cancer Research (published online June 2017; doi:10.1158/1078-0432.CCR-16-1761).

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Research presented at the 2017 American Society of Clinical Oncology showed that although human papillomavirus (HPV) vaccine reduces the rate of oral HPV infection, the vaccine is still underutilized among teens and young adults.

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PD-L1 expression may be a biomarker of local failure in human papillomavirus (HPV)-negative head and neck squamous cell carcinoma following radiotherapy, according to research published in Clinical Cancer Research (published online May 2017; doi:10.1158/1078-0432.CCR-16-2586).

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Patients aged 80 years or older with early-stage esophageal cancer who received treatment had an increased 5-year overall survival (OS) compared with those who received no treatment or observation alone, according to research published in the Journal of Thoracic Oncology (published online April 2017; doi:10.1016/j.jtho.2017.04.004).

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