A new clinical-genomic risk group classification may accurately identify patients at low, intermediate, and high risk for metastasis in localized prostate cancer.

Conferences

In the first study to evaluate patient-reported outcomes from the NRG Oncology/RTOG 0415 trial, treatment with hypofractionated radiation therapy offers similar health-related quality of life (HRQoL) outcomes in one-third less treatment time compared with conventional radiation therapy in men with early stage, low-risk prostate cancer, reported researchers at the 58th Annual Meeting of the Amer

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High-dose stereotactic body radiotherapy (SBRT) for men with newly-diagnosed low- or intermediate-risk prostate cancer results in shorter treatment times, low severe toxicity, and excellent cancer control rates, according to research presented at the 58th Annual Meeting of the American Society for Radiation Oncology (ASTRO) in Boston, MA (Sept 25-26).

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Patients with metastatic castrate resistant prostate cancer treated with enzalutamide (ENZ) may be more likely to experience central nervous system adverse events and fatigue than those who receive a combination of abiraterone acetate and prednisone (AA+P), according to the results of a poster presented at the American Society of Clinical Oncology Annual Meeting (June 3-7, 2016; Chicago, IL).

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News

A new clinical-genomic risk group classification may accurately identify patients at low, intermediate, and high risk for metastasis in localized prostate cancer.
Biopsies every 2 years, instead of annually, seem to be "an acceptable alternative" for acute surveillance of low-risk prostate cancer, according to a comparative analysis.
Positron emission tomography (PET)-based molecular imaging biomarkers may predict therapeutic response and survival in patients with metastatic castration-resistant prostate cancer (mCRPC).

Survival among men with de novo metastatic prostate cancer has improved since the introduction of several systemic agents for the treatment of castrate-resistant disease, according to a new population-based study published online in International Urology and Nephrology (doi: 10.1007/s11255-017-1744-2).

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Research in Review

Research suggests that age can impact the risk of disease progression in low-risk prostate cancer managed with active surveillance, published in the Journal of Clinical Oncology (June 2017;35[17]:1898-1904).

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Current National Comprehensive Cancer Network (NCCN) guidelines and Gleason scores cannot reliably stratify patients with risk of prostate cancer for the presence or absence of pathogenic germline variants, according to keynote presentation at the 2017 ASCO Annual Meeting (June 2-6, 2017; Chicago, IL).

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Groundbreaking results of a trial have shown that the combination of a new drug with androgen deprivation therapy (ADT) significantly improves overall survival (OS) and radiographic progression-free survival (PFS) in patients with high-risk metastatic hormone-naïve prostate cancer, presented at the 22017 ASCO Annual Meeting (June 2-6, 2017; Chicago, IL).

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A diagnostic magnetic resonance imaging (MRI) scan followed by an MRI-guided biopsy strategy is more cost-effective than an invasive transrectal ultrasound for detecting prostate cancer, according to research published in Radiology (published online May 2017; doi:10.1148/radiol.2017162181).

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